To design safe clinical trials, it is crucial to better understand and predict gene editing outcomes in preclinical studies. Bence György and collaborators have shown that adeno-associated viruses ...

Retroviral integration into host cell chromosomes was once thought to be random, but new evidence suggests that human immunodeficiency virus preferentially enters the neighborhood of activated genes.

A new vector system known as lentiviral vectors can permanently integrate the gene into dividing and non-dividing cells. The capacity of lentiviral vectors to reliably integrate at various genomic ...